678 Efficacy of topical LXR agonist in the treatment of primary cicatricial alopecia in Scd1−/− mouse
نویسندگان
چکیده
Primary cicatricial alopecias (PCAs) are heterogeneous disorders characterized by the replacement of hair follicle (HF) structures fibrous tissue, leading to permanent loss. The underlying pathogenesis and treatment options poorly due lack preclinical research models. asebia mouse, which harbors mutations in stearoyl-CoA desaturase 1 (Scd1) gene, was previously proposed as a model for PCA, however, immunopathogenic mechanisms loss Scd1−/− mice largely unknown. We found that intraepithelial CD207+ Langerhans cells (LCs) were significantly increased primarily within HF isthmus infundibulum epithelium, whose dendrites surrounded caspase-8-driven apoptotic epithelial cells. Flow cytometry revealed CD45+CD207mid LC population expanded compartments mice, not observed Scd1+/− mice. Thus, shares multiple immunologic features with human central centrifugal alopecia (CCCA). Systemic anti-CD207 antibody markedly attenuated progression loss, suggesting LCs driver postulated correction lipid synthesis defect would reverse LC-mediated pathogenic process. liver X receptor (LXRs) is considered master regulator cholesterol biosynthesis. Topical LXR agonist (GW3965) showed promising efficacy attenuation progressive reducing expansion. established mouse PCA induce immune-mediated Our findings invite further clinical evaluation agonists novel potential therapeutic agents PCA.
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2022
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2022.05.689